It is usually best to use as few fonts as possible. The more you use,
the harder it becomes to create a good-looking document.
In a typical document, you would use one font for the headings.
A sans-serif is often a good choice, because it is ‘accessible’,
easy to skim and read at-a-glance. This font could also be used
for other parts of the page that are designed to be read quickly
- captions or contents lists. Often the subhead will just be the
same typeface as a main heading, but at a smaller size. You would
then use a second font for the body copy. A serif is a good choice
here, because it is comfortable to read in long passages.
Although with some work, any font can be combined with any other,
as a general guide:
For a standard document, a Humanist sans serif for headings will
work well with either an Old-style or Transitional serif font. For
media will little text, such as signs, Geometric combines well with
Modern serifs and Grotesque combines well with Slab-serifs.
Above all, to ensure readibility and consistency, try to keep font
changes to a minimum.